Replace all instances of FINDTHIS with REPLACEWITHTHIS in columns COLUMN1 and COLUMN2 of table TABLE where those substrings are in fact found
update TABLE set
COLUMN1=REPLACE(COLUMN1,’FINDTHIS’,'REPLACEWITHTHIS’),
COLUMN2=REPLACE(COLUMN2,’FINDTHIS’,'REPLACEWITHTHIS’)
from TABLE
where
COLUMN1 like ‘%SUBSTRINGPIECE%’ or COLUMN2 like ‘%SUBSTRINGPIECE%’

